NRF2-dependent Epigenetic Regulation can Promote the Hybrid Epithelial/Mesenchymal Phenotype

NRF2-dependent Epigenetic Regulation can Promote the Hybrid Epithelial/Mesenchymal Phenotype

Blog Article

The epithelial-mesenchymal transition (EMT) is a cellular process critical for wound healing, cancer metastasis and embryonic development.Recent Intestinal parasitic infections in a community from Pampa del Indio, Chaco (Argentina) and their association with socioeconomic and environmental factors. efforts have identified the role of hybrid epithelial/mesenchymal states, having both epithelial and mesehncymal traits, in enabling cancer metastasis and resistance to various therapies.Also, previous work has suggested that NRF2 can act as phenotypic stability factor to help stablize such hybrid states.

Here, we incorporate a phenomenological epigenetic feedback effect into our previous computational model for EMT signaling.We show that this type of feedback can stabilize the hybrid state as compared to the fully mesenchymal phenotype Bio-Template Synthesis of V2O3@Carbonized Dictyophora Composites for Advanced Aqueous Zinc-Ion Batteries if NRF2 can influence SNAIL at an epigenetic level, as this link makes transitions out of hybrid state more difficult.However, epigenetic regulation on other NRF2-related links do not significantly change the EMT dynamics.

Finally, we considered possible cell division effects in our epigenetic regulation model, and our results indicate that the degree of epigenetic inheritance does not appear to be a critical factor for the hybrid E/M state stabilizing behavior of NRF2.